Columbus Crew 2

On December 6, 2021, the Columbus Crew announced the formation of a reserve team in MLS Next Pro that would begin play in the 2022 season and that they would play at Historic Crew Stadium (the parent club's former home venue) in Columbus, Ohio. At the same time, the club announced its first manager, Corey Wrey, who is the Crew's current Assistant General Manager, a position he will continue to hold. The Crew 2 will be one of 21 teams that play in the newly formed league. On January 28, 2022, the Crew announced that Laurent Courtois would serve as the team's first head coach.

The club played their first match on March 26, 2022, which ended in a 0–2 loss to Inter Miami CF II at DRV PNK Stadium. The first win came the following week with a 1–0 victory over Chicago Fire FC II.

Crew 2 won the first ever MLS Next Pro Cup title, defeating St. Louis City SC 2 4-1 on October 8, 2022.

The following year, the team once again qualified for the playoffs and made it to the Cup Final. They were defeated 1–3 by Austin FC II.