New England Revolution

First appearances in CONCACAF competitions (2003–2007)

The Revolution's first foray into international competition came in the 2003 CONCACAF Champions' Cup, for which they qualified as the runners-up in the 2002 MLS Cup. They faced Liga Deportiva Alajuelense of Costa Rica in a two-legged tie, where the winner is based on the sum (known as the aggregate score) of the scores of a home and an away match. Because of logistical issues, both matches were hosted in Costa Rica. The Revolution were considered to be unlikely to advance because of their lack of international experience. The first leg was played on March 23, 2003, and the Revolution suffered a 4–0 defeat which made it highly unlikely they would move on. In the second leg, played on March 26, goals from Taylor Twellman, Wolde Harris, and Steve Ralston brought the aggregate score within one. The comeback was put to a stop when Alajuelense substitute Rolando Fonseca scored and the Revolution's Shalrie Joseph and Daniel Hernández were sent off. The match ended with a 3–1 result, which was not enough to overturn the first-round deficit, and the Revolution were eliminated from the competition.

The Revolution's next appearance in continental competition was the 2006 CONCACAF Champions' Cup, where they once again played Alajuelense. This time, the team opted to play their home match at the Bermuda National Stadium, which was unpopular with fans who believed that a matchup in March in Foxborough would play to their advantage. However, team officials worried that with the unpredictable weather and poor temperatures, they would need to play on an artificial surface rather than the natural grass surface of Gillette Stadium, which would raise the risk of injury. The first match (the "home" match) was played to a scoreless draw. On the March 9 away leg in Alajuela, Alajuelense's Carlos Hernández scored a 90th minute free kick, which sealed a 1–0 result and the Revolution's elimination.

Two years later, the Revolution again qualified for the competition, which had been rebranded to the CONCACAF Champions League, the name it would hold until the 2023 season. This time, they faced off against Trinidadian champions Joe Public F.C. in the preliminary round. The Revolution were left with a small 2–1 deficit after the away leg in Trinidad, but in the home leg, they were defeated 4–0. This marked the first time an MLS team had lost to a team from the Caribbean in CONCACAF competition, and the first time a side from Trinidad had put up more than three goals against an MLS side.

Return to CONCACAF competitions (2022–2024)

It took until the 2022 CONCACAF Champions League for the Revolution to make another appearance in CONCACAF competition. This time, they qualified as winners of the MLS Supporter's Shield, which they won in the 2021 season. The Revolution was scheduled to play Cavaly AS of Haiti in the Round of 16, although this matchup was cancelled after the Haitian side failed to secure visas. The team advanced to face Pumas UNAM of Mexico. The first leg was played in snowy conditions at Gillette Stadium, and the Revolution won the match 3–0, which was the first time they held an aggregate lead in official CONCACAF competition. On the away leg, the Revolution were missing starters Andrew Farrell, Matt Turner, and Henry Kessler. They conceded three goals without scoring a goal of their own and were eliminated when they lost 4–3 in a penalty shootout. This loss marked only the second time in the tournament's history that a team with a 3–0 lead in the first leg failed to advance.

The Revolution next qualified for the 2024 tournament, which had rebranded again as the Champions Cup. This time they qualified as a result of their regular season standings the previous year. They were matched against C.A. Independiente de La Chorrera of Panama, winning the road leg 1–0 on February 21 and the home leg 3–0 on February 29. In the second round, they faced Alajuelense, in what was the third time the teams had faced off across the Revolution's five appearances in the tournament. This time, the Revolution won 4–0 at home on March 6 and drew 1–1 on the road on March 14, an aggregate win. They advanced to face Club América. Despite having earned the right to host the second leg of the tie due to their superior record in the competition, the club requested to reverse the order of the ties due to a scheduling conflict with SuperCross at Gillette Stadium. The Revolution were eliminated after losing the home leg 4–0 and the away leg 5–2 at Estadio Azteca.