Karditsa

Anagennisi was formed on October 16, 1904, in the southwestern Thessalian city of Karditsa as the football team of the multisport club ASA (Greek: Αθλητικός Σύλλογος Αναγέννησης - Athlitikos Syllogos Anagennisis), the Athletic Association Anagennisi. The statute of the club was signed personally by Crown Prince Constantine I.

The first Olympic Games in Greece, in 1896, created the conditions for the creation of an athletic club in the city of Karditsa.

From its inception in 1904, the football team of Anagennisi was not officially recognized as a distinct entity within the organization. As more of the club's athletes began to show interest in the sport, the football team began to train and play locally organized games in the stadium of central Karditsa, which later became Pavsilipo Park. With the sport's expanding popularity in Greece in the following decades, in 1924 the football team was finally given its department within ASA. Playing in the independent, regional Thessalian League from 1929 to 1962, it joined the newly established Greek second division in time for the 1962–63 season. When the Greek football league became professional in 1979, the football department of ASA was reformed as FC [a Football Public Limited Company, or PAE (Greek: ΠΑΕ - Ποδοσφαιρική Ανώνυμη Εταιρία / Podosferiki Anonymi Eteria) and continued to compete as PAE Anagennisi Karditsas (FC Anagennisi Karditsa)].

One of the highlights in Anagennisi Karditsa's history is the victory over Olympiacos for the Greek Cup in 1993–94, as well as the win against Paniliakos for the Greek semi-professional cup final in 1981. In 2008, Anagennisi Karditsa reached the Gamma Ethniki play-off and beat Ilioupoli 2–0 in Athens to win promotion to Beta Ethniki, which was the second tier league until 2019.

Anagennisi Karditsa holds the record for the most fans to ever attend an away game for Gamma Ethniki in 2008, with 2,000 supporters in the play-off match against Ilioupoli. In the 2008–09 season, Anagennisi Karditsa had the fourth best average in attendance, despite having only avoided relegation in the last fixture against Veria.

In December 2021, for the first time in its history, the club reached the Greek Cup quarterfinals, commonly referred to as the "eight" of the Greek Cup.

On 16 October 2024, Anagennisi Karditsa FC celebrated the 120th anniversary of its foundation.

Anagennisi Karditsa participated in Super League 2 for the 2025–26 season.